![]() ![]() Lyme disease is the most commonly reported tick-borne infection in North America and Europe, causing an estimated 300,000 cases in the United States each year and 85,000 cases in Europe. Nearly all human infections are caused by 3 Bbsl species B burgdorferi sensu stricto (hereafter referred to as B burgdorferi) is the primary cause of Lyme disease in North America, while Borrelia afzelii and Borrelia garinii are the primary causes of Lyme disease in Europe and parts of Asia. ![]() Lyme disease is a multisystem and multistage tick-transmitted infection caused by spirochetal bacteria in the Borrelia burgdorferi sensu lato (Bbsl) complex. Centrifuge and aliquot serum into a plastic vial. A serum sample of 1.2 mL needs to be collected within 24 hours of the spinal fluid specimen, preferably at the same time.Ģ. CSF aliquot should be from the second, third, or fourth CSF vial collected during the lumbar puncture.ĭo not submit CSF from the first vial due to the possibility of blood contamination, which will cause specimen rejection. A spinal fluid (CSF) sample of 1.2 mL needs to be collected within 24 hours of the serum specimen, preferably at the same time.ģ. CSF and serum must be collected within 24 hours (maximum) of each other.ġ. Meningitis/Encephalitis Panel Algorithmīoth spinal fluid (CSF) and serum are required for this test. Acute Tick-Bourne Disease Testing Algorithm Lyme Neuroborreliosis Diagnostic Algorithm This testing is performed at an additional charge. These additional tests are necessary in order to normalize the level of anti- Borrelia antibodies to total IgG and albumin in the CSF and establish the antibody index ratio of anti- Borrelia antibodies in CSF-to-serum. Anti- Borrelia species IgG levels in CSF and serum In order to establish the antibody index, the paired serum and CSF samples (collected within 24 hours of each other) are tested on the same run using quantitative assays to determine levels for the following analytes:ġ. If the screen is positive, the paired CSF and serum specimens will be used to establish the antibody index. ![]() If the screen is negative, no additional testing will be performed. This test begins with IgG screening of the spinal fluid specimen. ![]()
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